After receiving four proposals, CMT was designated as the appropriate choice. Director of the Parks Department Bob Pfeiffer said with this planning phase of the development, CMT will be going in-depth on all surrounding details. Its just getting the general, basic idea for how its going to be designed, the utility placements and drainage placements all of those issues including roadway considerationsits also going to take into consideration the neighboring communities so to speak and the residents that live in those neighborhoods with the buffering of sound and lighting, Pfeiffer said. CMT will also consider regional use of the facility, aside from strictly local use from the sports teams. This will also include looking at a regional not just whats in Madison/St. Clair county. It would take a look at the immediate area, like the one-hour commute out, and another reach out as far as if we would be looking at some type of regional draw; what we would think we could anticipate, Williams said. They would also work with our turf consultant to see, as far as tolerance for rain out events, even with the local leagues, what kind of rainout tolerance how quick they could turn the fields around and if they want to play on the fields seven days a week, four days a week because that affects the quality of the turf. After the planning phase is complete, a separate Design and Construction Engineering Agreement will be submitted to City Council for review based on schedule, scope, and budget. City Administrator Tim Harr said this planning process is the first step in the overall development of the facility. click over here nowTo me, its going to be an incremental or a phased process where were going to collect the information and then really the City Council will have to make a determination with the decisions on how we proceed forward with the design of these things. What is our intent? Is our intent solely to accommodate the existing teams we have in the community or will we be able to accommodate other teams coming in? That will make a big difference on the type of turf and the amenities, Harr said.
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The study included both transplant-eligible (TE) and transplant non-eligible (TNE) patients. Patients received induction treatment in both segments with lenalidomide or thalidomide plus cyclophosphamide and dexamethasone. TE patients proceeded to a standard melphalan 200mg/m2 autologous stem cell transplant (ASCT). Patients were then randomized to either maintenance lenalidomide or observation after achieving maximum response (TNE) or at 100 days after transplant (TE). Lenalidomide maintenance was administered at a dose of 10mg daily in 21/28 day cycles until disease progression. Overall, the primary endpoint of progression-free survival (PFS) was 36 months for patients receiving lenalidomide (n=857) and 18 months for observation (n=694) (HR:0.45 95% CI [0.39, 0.52] P < 0.0001) in the maintenance phase of the study. For TE patients, median PFS was 50 months for lenalidomide (n=451) and 28 months for observation (n=377) (HR:0.48 95% CI [0.38, 0.60] P < 0.0001). For TNE patients, median PFS was 24 months for lenalidomide (n=406) and 11 months for observation (n=317) (HR:0.42 95% CI [0.35, 0.60] P < 0.0001). Grade 3-4 adverse events for patients receiving lenalidomide (n=864) included neutropenia (34%), thrombocytopenia (7%) and anemia (4%).
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